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(Courtesy of C P Panayiotopoulos. From: Panayiotopoulos CP. The epilepsies: seizures, syndromes and management. Oxford: Bladon Medical Publishing, 2005.)
Sep. 05, 2020
Epilepsy & Seizures
Epilepsy surgery continues to expand in clinical use as an effective treatment for correctly selected patients with medically intractable and disabling focal epilepsy. Presurgical evaluation should delineate the epileptogenic zone, and epilepsy surgery includes both resective and disconnective procedures. Outcome measures of epilepsy surgery include (1) seizure control and (2) quality of life.
Nov. 04, 2008
Neuropharmacology & Neurotherapeutics
Zonisamide is chemically classified as a sulfonamide and is unrelated to other antiepileptic drugs. It is indicated for the treatment of partial seizures in adults with epilepsy and has many off-label uses. Zonisamide, as monotherapy or adjunctive therapy, has been demonstrated to be safe, effective, and well tolerated as a long-term treatment option in patients with various seizure types.
Apr. 01, 2021
Common features of superficial siderosis include progressive sensorineural hearing loss, cerebellar ataxia, pyramidal signs, ataxia, and headache. It is caused by recurrent subarachnoid hemorrhage with accumulation of hemosiderin and other iron-containing pigments in the leptomeninges, brain surface, brainstem, cerebellum, cranial nerves, and spinal cord, and may be progressively disabling or fatal.
Oct. 21, 2020
Childhood Degenerative & Metabolic Disorders
Aug. 17, 2021
Autonomic neuropathies consist of acquired or inherited diseases resulting from a disturbance of the peripheral autonomic nervous system. Clinical features vary depending on relative involvement of distal sympathetic, cholinergic, or adrenergic systems.
Aug. 09, 2019
Carnitine-acylcarnitine translocase deficiency is a rare inborn error of energy metabolism involving the carnitine cycle. This enzyme deficiency is considered
Feb. 20, 2021
Acute necrotizing hemorrhagic leukoencephalitis is a disorder that often follows a virus or mycoplasma infection and evolves rapidly to coma and death. Lesions are hemorrhagic, with fibrinoid necrosis and polymorphonuclear neutrophil infiltration that is associated with demyelination. The devastating immune response may be from excess sensitization to 1 or more unknown antigens. COVID-19 infection induces acute necrotizing hemorrhagic leukoencephalitis.
Mar. 26, 2021