This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.

Anthrax toxin formation and activity

Download

Note the binding of protective antigen to anthrax toxin receptors on the cell surface, with subsequent proteolytic processing and oligomerization to form a heptamer, which binds edema factor and lethal factor. LF and EF can bind to the PA heptamer (PA7mer) to form lethal toxin (LT) or edema toxin (ET), which associate with lipid rafts. These complexes are then internalized via endocytosis, and through a translocation process lethal factor and edema factor can enter the cytoplasm. (Source: Bower WA, Hendricks K, Pillai S, Guarnizo J, Meaney-Delman D, Centers for Disease Control and Prevention (CDC). Clinical framework and medical countermeasure use during an anthrax mass-casualty incident. MMWR Recomm Rep 2015;64(4):1-22. Public domain.)