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Dissociation curves of carbon monoxide-hemoglobin in the presence of a constant percentage of carbon monoxide and varying percentage of oxygen at atmospheric pressure

The points determined lie on the rectangular hyperbolas drawn through them until the dotted portions of the curves are reached for mice with very low percentages of oxygen and carbon monoxide. "The existence of the hump points to the conclusion that the presence of reduced haemoglobin has a powerful influence of some kind in preventing CO [carbon monoxide] from combining with haemoglobin." Key: I, blood of John S Haldane (Sr.), CO=0.0945%; II, blood of mouse C, CO=0.090%; III, blood of mouse D, CO=0.0635%. (Source: Douglas CG, Haldane JS, Haldane JB. The laws of combination of haemoglobin with carbon monoxide and oxygen. J Physiol 1912;44(4):275-304.)

Associated Disorders

  • Anoxic leukoencephalopathy
  • Carbon monoxide-induced parkinsonism
  • Delayed carbon monoxide encephalopathy
  • Late sequelae of carbon monoxide poisoning
  • Warehouse workers headache