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MRI pattern B2: MRI in adult patient with Krabbe disease

Relatively isolated signal changes of the pyramidal tract (arrows, T2-weighted sagittal on the left, axial FLAIR image on the right). The cerebellum shows no signal changes. Case with onset at 60 years, and age 69 years at MRI). (Source: Krieg SI, Krägeloh-Mann I, Groeschel S, et al. Natural history of Krabbe disease: a nationwide study in Germany using clinical and MRI data. Orphanet J Rare Dis 2020;15[1]:243. Creative Commons Attribution 4.0 International License, https://creativecommons.org/licenses/by/4.0.)

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  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy