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The reaction shown at the bottom of the diagram is the conversion of gamma-glutamyl-cysteine and glycine to glutathione by glutathione synthetase. (Contributed by Dr. Douglas Lanska.)
Aug. 05, 2020
Epilepsy & Seizures
Tonic status epilepticus manifests with repetitive series of frequent tonic seizures that may last for weeks or months, progressing to autonomic manifestations, including respiratory depression, which may lead to death. It occurs mainly in children with neurocognitive impairment and severe epilepsy, such as Lennox-Gastaut syndrome.
Feb. 05, 2020
Jan. 18, 2021
2-hydroxyglutaric acidurias belong to organic acidurias. They represent inherited disorders, each with a characteristic symptomatology, MR-pattern, and
Oct. 06, 2016
Neuro-Ophthalmology & Neuro-Otology
Horner syndrome is an eponym used to describe the clinical triad of ptosis, miosis, and anhidrosis caused by interruption of the ipsilateral first-, second-, or third-order sympathetic neurons to the head, eye, and neck. The hallmark of Horner syndrome is ptosis and miosis on the same side. When Horner syndrome is suspected, pharmacologic testing should be performed to confirm the diagnosis.
Jan. 29, 2021
Jan. 19, 2021
Stroke & Vascular Disorders
In this article, the author reviews current knowledge about intracranial aneurysms due to infectious and neoplastic causes. Direct mural injury or invasion
Jul. 21, 2021
Childhood Degenerative & Metabolic Disorders
Canavan disease is a degenerative neurologic condition characterized by aspartoacylase deficiency, resulting in a spongy deterioration of the brain. It is due to mutations in the ASPA gene encoding the aspartoacylase enzyme that catalyzes the conversion of acetylaspartic acid (NAA) to aspartate and acetate. Diagnosis of Canavan disease can be achieved by examining urine NAA.
May. 25, 2019