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Midsagittal tissue block in fetus with spina bifida

Left schematic drawing and right histological sagittal paraffin section of a midsagittal tissue block from the sella turcica region in a human fetus with spina bifida in the lumbosacral region, 19 weeks of gestation. Anterior direction is left. The sella turcica appears malformed in the lower anterior wall. Adenopituitary tissue is located in the sella turcica and in the pharyngeal submucosa. Neuropituitary gland tissue was found within the sella. (Toluidine blue) (Reproduced with permission. Pediatr Pathol Lab Med 1996;16:909-26.)

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Associated Disorders

  • Anencephaly
  • CHARGE syndrome
  • Cleft lip and palate
  • Duplication of pituitary stalk
  • Ectopic neurohypophysis
  • Empty sella syndrome
  • Holoprosencephaly
  • Hypertelorism
  • Midfacial anomalies
  • Myelomeningocele
  • Pallister-Hall syndrome
  • Pituitary agenesis
  • Pituitary aplasia
  • Pituitary dysplasia
  • Pituitary ectopia
  • Pituitary hypoplasia
  • Rachischisis
  • Rathke cleft cyst
  • Rieger syndrome
  • Rubinstein-Taybi syndrome
  • Septo-optic dysplasia
  • Solitary maxillary central incisor
  • Spina bifida