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Nonenhanced cranial CT scan showing right hemispheric cerebral contusion and extensive midline shift. (Contributed by Dr. Ravindra Kumar Garg.)
Apr. 06, 2020
Apr. 25, 2020
Testing directly for LGI1 and contactin-associated protein 2 (CASPR2) antibodies should be undertaken in patients with clinical features suggestive of faciobrachial dystonic seizures, limbic encephalitis, Morvan syndrome, and neuromyotonia. LGI1-antibody seropositivity is most commonly associated with limbic encephalitis, with a high incidence of seizures and cognitive impairment. There is significant overlap in clinical manifestations with CASPR2 seropositivity, with neuromyotonia, pain, and sleep disturbance occurring across both clinical entities, albeit at different frequencies.
Jun. 08, 2020
Childhood Degenerative & Metabolic Disorders
GLUT1 deficiency syndrome is a metabolic disorder due to defective transport of glucose across the blood-brain barrier. The classic picture is that of a child with refractory seizures starting in infancy, developmental delay, acquired microcephaly, hypotonia, and a movement disorder typically consisting of ataxia, spasticity, and dystonia. Increasingly, milder phenotypes are being recognized, including patients with normal cognition, early-onset absence or other generalized epilepsy, paroxysmal dystonia, or other movement disorders with and without epilepsy.
Oct. 21, 2020
Nov. 03, 2020
Anti-NMDA receptor encephalitis is an autoimmune disorder mediated by specific IgG autoantibodies to the GluN1 subunit of the NMDA receptor. Most patients present with neuropsychiatric symptoms that progress to include seizures, movement disorders, autonomic dysfunction, and decreased level of consciousness. The underlying mechanism of the disorder is a reversible antibody-mediated reduction of synaptic NMDA receptors.
May. 12, 2021
Changes in sex-hormone levels during menarche, menstruation, pregnancy, and menopause may affect the prevalence and character of migraine and other types of headaches. Migraine occurring with menses may be characterized as menstrual migraine, menstrual-associated migraine, and non-migrainous perimenstrual headache. Migraine typically improves during pregnancy, mostly in the second and third trimesters. After menopause, when sex hormone levels stabilize, most women have improvement.
Oct. 23, 2016
Neurogenetics encompasses heritable disorders in all the subspecialties of neurology and is an ever-growing field. New technologies such as next-generation
Oct. 07, 2019