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California serogroup (La Crosse) encephalitis virus (cycle)

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The inapparent cycle of the La Crosse virus is between Aedes triseriatus, a woodland mosquito, and chipmunks and tree squirrels. The virus is maintained over winters by transovarian transmission and is amplified by venereal transmission between the infected male nonbiting mosquito and the uninfected female, which can in turn transmit either by biting or by transovarian transmission to the next generation. Humans are the only known host to develop clinical disease and are a dead-end host for the virus. (Used with permission: Johnson RT. Viral infections of the nervous system. 2nd ed. Philadelphia: Lippincott-Raven, 1998:87-132.)