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An axial T1-weighted MRI shows cortical atrophy in Sturge-Weber syndrome. Arrows indicate extensive cortical atrophy on the affected left hemisphere. (Contributed by Dr. Anne Comi.)
Neuropharmacology & Neurotherapeutics
Mar. 10, 2021
Childhood Degenerative & Metabolic Disorders
Aug. 13, 2021
Headache & Pain
Pain is generally defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Pain can be acute or chronic and is an important symptom of neurologic disorders. Management of chronic pain, particularly neuropathic pain, is a challenge. An understanding of the pathomechanisms of various types of pain is helpful in developing a management strategy.
Nov. 12, 2020
High-dose intravenous immune globulin (IVIG) has been used for the treatment of autoimmune disorders since 1981, starting with idiopathic thrombocytopenic purpura. IVIG is a safe and effective therapy for Guillain-Barré syndrome, but some cases may not respond to it or may get worse. IVIG is the preferred first-line treatment for chronic inflammatory demyelinating polyradiculoneuropathy and an adjunctive therapy for myasthenia gravis where no other therapy is effective.
Mar. 08, 2021
Oct. 13, 2020
Advances in the molecular biology of genetic disorders and the identification of gene mutations have enabled molecular diagnosis of these disorders. Molecular diagnostics are important for screening and as adjuncts to the clinical diagnosis of neurogenetic disorders. Next generation sequencing will improve the management and gene therapy of neurogenetic disorders in the era of personalized medicine.
Oct. 12, 2020
Neuro-Ophthalmology & Neuro-Otology
Vertigo is an illusion of movement due to an imbalance of tonic vestibular activity within the central or peripheral vestibular pathways. Vertigo is usually rotatory, implying a disturbance of the semicircular canals or their central connections. Sensations of body tilt or impulsion indicate otolithic disturbances or dysfunction of central otolithic connections. Vertigo is commonly associated with nystagmus, oscillopsia, postural imbalance, and autonomic symptoms.
Oct. 21, 2020
Natalizumab (trade name Tysabri) is an immunosuppressive drug used for the treatment of relapsing-remitting or relapsing secondary progressive multiple sclerosis, as a second-line therapy in patients who do not respond to first-line agents. It is a selective adhesion molecule inhibitor that blocks the ability of alpha4 beta1 integrin to bind to its receptor, the vascular cell adhesion molecule.
Mar. 01, 2021