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Yearly and cumulative incidence of PML by treatment epoch

Incidence of progressive multifocal leukoencephalopathy (PML) by epochs of 12 infusions, compared with cumulative incidence, per 1000 natalizumab-treated patients. X-axis shows epochs of 12 infusions, or approximately one year of therapy. Polynomial curve fitting of means per epoch. Data from Biogen, January-September, 2013. (Contributed by Dr. Anthony Reder.)

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Associated Disorders

  • AIDS
  • CNS lymphoma
  • autoimmune diseases
  • leukemia
  • progressive multifocal leukoencephalopathy
  • tuberculosis