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Close view of an 8-year-old Ghanaian boy's perianal region, which exhibited papillomatous lesions that were present for 1 week, due to yaws

The first sign of yaws is the appearance of a painless papule that grows into a papilloma. These early granulomatous lesions are characterized by a yellow-crusted appearance and are highly infectious. (Source: Photography by Dr. Peter Perine, Centers for Disease Control and Prevention, 1979. Public Health Image Library [PHIL] ID# 3837, Centers for Disease Control and Prevention, Atlanta, Georgia. Public domain.)

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