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Low-affinity, high-capacity folate transporters in the renal tubular epithelium

Low-affinity, high-capacity folate transporters expressed at the apical and basolateral membranes of the renal tubular epithelium also contribute to renal folate transport.

Legend: BCRP: breast cancer resistance protein, an efflux transporter; Glu: glutamate; 5-methyl-THF: 5-methyl-tetrahydrofolate; MRP: multidrug resistance-associated protein; OAT: organic anion transporter; RFC: reduced folate carrier. (Source: Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26(12):3731.) (Modified by Dr. Douglas Lanska. Creative Commons Attribution 4.0 [CC BY] license.)