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Glutathione synthetization

Glutathione is synthesized in the cytoplasm of cells and is imported to the mitochondria where it functions as a cofactor for a number of antioxidant and detoxifying enzymes. Legend: ADP=adenosine diphosphate; ATP=adenosine triphosphate; Cys=cysteine; γ-GCS= γ-glutamyl cysteine synthase; Glu=glutamate; Gly=glycine; GS=glutathione synthetase; GSH=glutathione (cytoplasmic); mGSH=glutathionie (mitochondrial). (Source: Ribas V, García-Ruiz C, Fernández-Checa JC. Glutathione and mitochondria. Front Pharmacol 2014;5:151. Creative Commons Attribution license.)