10393 San Diego Mission Rd, Suite 120
San Diego, CA 92108-2134
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Post-contrast T1-axial and coronal imaging shows multiple small ring-enhancing nodules at ambient and quadrigeminal cisterns. (Contributed by Dr. Gaurang V Shah.)
Behavioral & Cognitive Disorders
Jul. 04, 2020
Congenital muscular dystrophy presents at birth or within the first months of life with weakness, hypotonia, and delayed motor milestones, as well as contractures, and mental retardation in some cases. Clinical severity ranges from milder forms with survival into adulthood, to severe presentations with substantially shortened lifespan and frequent association with cerebral involvement.
Nov. 23, 2020
Epilepsy & Seizures
Epilepsy with progressive mental retardation (Northern epilepsy syndrome) is a subtype 8 of neuronal ceroid lipofuscinosis (CLN8 disease) described in
May. 31, 2021
General Child Neurology
Hereditary ataxias are characterized by degeneration of the cerebellum and spinal cord. Friedreich ataxia (FRDA), caused by a GAA trinucleotide (triplet) repeat expansion mutation, is the most common nondominant form. A childhood onset spinocerebellar ataxia (SCA), FRDA is associated with scoliosis, cardiomyopathy, and absent knee and ankle jerks.
Apr. 16, 2021
Episodes of periodic paralysis typically involve generalized muscle weakness with hypotonia and areflexia but spare bulbar and respiratory muscles and cognition. During attacks, affected muscles are in a state of sustained depolarization and are electrically inexcitable. Attacks may last minutes, hours, or even days. Episodes are often precipitated by specific triggers (behavior/diet) or are associated with abnormal serum potassium levels.
Dec. 05, 2019
Sciatic neuropathy presents acutely with foot weakness, pain, and sensory loss, with weakness commonly manifested as a foot drop. It can be caused by a focal lesion of the sciatic nerve in the hip or thigh from trauma, compression, or other etiologies.
Jun. 02, 2021
Neuropharmacology & Neurotherapeutics
Aug. 24, 2021
The author reviews the clinical neurotoxicity of the antiarrhythmic agent amiodarone, an amphiphilic drug that forms intralysosomal lipid complexes in
Feb. 16, 2021