Stroke & Vascular Disorders
Cardioembolic stroke is one of the more devastating causes of stroke. Significant progress has been made in identifying patients at high risk for cardioembolic
Mar. 06, 2018
Homocysteine is converted to methionine by receiving a methyl group from 5-methyltetrahydrofolate (active form of folate; betaine). Irreversible removal of homocysteine occurs via the transsulphuration pathway, which combines Hcy with serine to form cystathionine. B6: vitamin B6, B12: vitamin B12, BHMT: betaine homocysteine methyltransferase, CBS: cystathionine beta synthase, CTH: cystathionine gamma ligase, DH: dihydro, DMG: dimethylglycine, HCy: homocysteine, Met: methionine, MS: methionine synthase (MTR gene), MHTFR: methylenetetrahydrofolate reductase, TH: tetrahydro. Adapted from (Larsson et al 2019).