Mucolipidosis II alpha/beta and mucolipidosis III alpha/beta
Jan. 14, 2020
Homocysteine is converted to methionine by receiving a methyl group from 5-methyltetrahydrofolate (active form of folate; betaine). Irreversible removal of homocysteine occurs via the transsulphuration pathway, which combines Hcy with serine to form cystathionine. B6: vitamin B6, B12: vitamin B12, BHMT: betaine homocysteine methyltransferase, CBS: cystathionine beta synthase, CTH: cystathionine gamma ligase, DH: dihydro, DMG: dimethylglycine, HCy: homocysteine, Met: methionine, MS: methionine synthase (MTR gene), MHTFR: methylenetetrahydrofolate reductase, TH: tetrahydro. Adapted from (Larsson et al 2019).