Isolated beta-methylcrotonyl-CoA carboxylase deficiency
Dec. 09, 2022
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Metabolites of coprine inhibit aldehyde dehydrogenase. If alcohol is ingested hours to days later, the affected individual experiences a constellation of symptoms identical to that from drinking alcohol after taking disulfiram: headache, nausea, vomiting, flushing, tachycardia, and, rarely, hypotension. (Public domain.)