Neuro-Ophthalmology & Neuro-Otology
Systemic small-vessel vasculitis
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is the current nomenclature for small-vessel vasculitides, including microscopic polyangiitis, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis. All affect small vessels and involve autoantibody formation against the antigens proteinase 3 and myeloperoxidase. The most commonly affected tissues are the upper and lower respiratory tract, kidneys, skin, and peripheral nerves. Acute exacerbations may be accompanied by nonspecific inflammatory symptoms, such as arthralgia, fever, and myalgia.
Dec. 28, 2016