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Amyloid precursor protein, amyloid beta protein, and pathogenetic mutations

Location of genetic defects leading to some hereditary forms of cerebral amyloid angiopathy are shown. (Contributed by Dr. Jeffrey L Saver.)

Associated Disorders

  • Alzheimer disease
  • Arteriovenous malformations
  • CAA
  • Cavernous hemangiomas
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
  • Cerebral venous thrombosis
  • Chronic traumatic encephalopathy
  • Coagulopathies
  • Dementia with Lewy bodies
  • Diffuse arteriosclerosis
  • Down syndrome
  • Fabry disease
  • Fibromuscular dysplasia
  • Hemorrhage into cerebral neoplasms
  • Hypertensive hemorrhage
  • Hypertensive vasculopathy
  • Infratentorial superficial siderosis
  • Intracerebral hemorrhage
  • Ischemic stroke
  • Leukoaraiosis
  • Lobar hemorrhage
  • Malignant hypertension
  • Malignant neoplasms and radiation necrosis
  • Memory loss
  • Moyamoya disease
  • Mycotic aneurysms
  • Nontraumatic intracerebral hemorrhage
  • Other dementias
  • Primary CNS angiitis
  • Prion disease
  • Seizures
  • Superficial siderosis
  • Trauma
  • VCID
  • Vascular cognitive impairment and dementia
  • Vasculitis