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Congenital muscular dystrophy: merosin deficient form (muscle histology showing absence of laminin alpha2)

Merosin immunolabeling in normal (A) and merosin-deficient (B) muscles were done with monoclonal antibody to the C-terminal portion of merosin, which was coupled to Texas red. Note the complete absence of bright signal from the surface of muscle fibers in B (magnification: 200x). (Contributed by Dr. Gyula Acsadi.)

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Associated Disorders

  • Fukuyama muscular dystrophy
  • Muscle-eye-brain disease
  • Walker-Warburg disease