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Neisseria meningitidis infects trigeminal Schwann cells (schematic)

N meningitis infects trigeminal Schwann cells, resulting in the formation of multinuclear cells or cells with budding nuclei or horseshoe nuclei. (Source: Delbaz A, Chen M, Jen FE, et al. Neisseria meningitidis induces pathology-associated cellular and molecular changes in trigeminal Schwann cells. Infect Immun 2020;88[4]:e00955-19. Creative Commons Attribution 4.0 International License, http://creativecommons.org/licenses/by/4.0.)

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Associated Disorders

  • asplenia
  • deficiency of a terminal complement component (C5-9)
  • deficiency of properdin