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Interactions of N. meningitidis at the nasopharyngeal surface

Following acquisition, Neisseria meningitidis (Nme) must survive against host defenses and interactions with other members of the microbiome to inhabit the mucus of the nasopharynx. Eventual binding of the epithelial surface results in passage into the submucosa by transcytosis. (Source: Mikucki A, McCluskey NR, Kahler CM. The host-pathogen interactions and epicellular lifestyle of Neisseria meningitidis. Front Cell Infect Microbiol 2022;12:862935. Creative Commons Attribution 4.0 International License,

Associated Disorders

  • asplenia
  • deficiency of a terminal complement component (C5-9)
  • deficiency of properdin