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Interactions of N. meningitidis in the systemic circulation

In the bloodstream, Neisseria meningitidis (Nme) must resist antibody- and complement-mediated killing, acquire iron, and attach to the capillary endothelial surface to form microcolonies. Once attached, Neisseria meningitidis possesses several mechanisms to resist the actions of phagocytic cells, including neutrophils and macrophages. (Source: Mikucki A, McCluskey NR, Kahler CM. The host-pathogen interactions and epicellular lifestyle of Neisseria meningitidis. Front Cell Infect Microbiol 2022;12:862935. Creative Commons Attribution 4.0 International License, http://creativecommons.org/licenses/by/4.0.)

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Associated Disorders

  • asplenia
  • deficiency of a terminal complement component (C5-9)
  • deficiency of properdin