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Superficial siderosis: iron deposits accompanied by reactive astrocytes in superficial cortex

Superficial cortical tissue from the right frontal lobe (GFAP immunohistochemistry). Within the superficial cortex area, iron deposits are accompanied by reactive astrocytes (arrowheads). (Source: Friedauer L, Foerch C, Steinbach J, et al. The acute superficial siderosis syndrome: clinical entity, imaging findings, and histopathology. Cerebellum 2023;22[2]:296-304. Creative Commons Attribution 4.0 International [CC BY 4.0] license,

Associated Disorders

  • Ataxia
  • Peripheral vestibular disorders
  • Sensorineural hearing loss
  • Subarachnoid hemorrhage