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Relationship of the folate cycle to other biochemical pathways

The cyclic interconversions of the folate cycle are closely connected with thymidine synthesis (needed for DNA synthesis), trans-sulfuration, methionine synthesis (remethylation from homocysteine), and the methylation cycle (used for control of genes). (Source: Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26(12):3731.) (Creative Commons Attribution 4.0 [CC BY] license.)