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Purine catabolism and salvage pathways

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Degradation pathways are in black, whereas the salvage pathway is in blue. Numbered items and abbreviations: PNPase—polynucleotide phosphorylase; (1) nucleotidase; (2) guanine deaminase. Note that hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is the same as hypoxanthine phosphorybosyltransferase (HPRT); these simply reflect different naming conventions. (From: Mileti LN, Baleja JD. The role of purine metabolism and uric acid in postnatal neurologic development. Molecules 2025;30[4]:839. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)