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Diffuse white matter hyperintensity in Lesch-Nyhan disease (MRI)

Axial T2-weighted brain magnetic resonance image of a 2-month-old boy with Lesch-Nyhan disease showing diffuse white matter hyperintensity. (Source: Yang L, Guo H. Case report: early-onset renal failure as presenting sign of Lesch-Nyhan disease in infancy. Front Pediatr 2022;10:1080486. Creative Commons Attribution License [CC BY], https://creativecommons.org/licenses/by/4.0.)

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  • Hyperuricemia
  • Intellectual disability
  • Renal stones