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Crystalline urine in a boy with Lesch-Nyhan disease

(A) Small white crystals deposited in urine. (B) Small crystals after centrifugal precipitation. (C) Photomicrograph (x200) of square columnar magnesium ammonium phosphate (struvite) crystal with strong refraction (black arrow). (Source: Li L, Qiao X, Liu F, et al. Description of the molecular and phenotypic spectrum of Lesch-Nyhan disease in eight Chinese patients. Front Genet 2022;13:868942. Creative Commons Attribution License [CC BY],

Associated Disorders

  • Choreoathetosis
  • Dystonia
  • Gout
  • Hyperuricemia
  • Intellectual disability
  • Renal stones