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Abnormal caffeine test

Caffeine is added to a final concentration of 0.5mM. A small increase (less than 0.2 gm) in baseline is seen, with an increase in twitch height. When the final concentration is 1 mM, the baseline rises by 0.6 g, and at 2 mM by a further 1.9 g. Normal muscle will produce a baseline contracture at 4, 8, and 32 mM. (Contributed by Dr. Jordan Miller.)

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Associated Disorders

  • Central core disease
  • Duchenne muscular dystrophy
  • Hypokalemic periodic paralysis
  • King-Denborough syndrome
  • Multi-minicore disease
  • Myoglobinuria
  • Neuroleptic malignant syndrome