Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Schematic of dystroglycan glycosylation and glycosyltransferase function

Dystroglycan is a transmembrane protein connecting the cell to extracellular ligands, such as laminin. Alpha- and beta-dystroglycan (DG) are shown in purple. The site of action of each glycosyltransferase mutated in dystroglycanopathies is indicated at the respective bonds on the functional glycan. Abbreviations: Man= mannose, GlcNac=N-acetylglucosamine, GalNac=N-acetylgalactosamine, Gal=galactose, RboP=ribitol phosphate, Xyl=xylose, GlcA=glucuronic acid. (The figure was partially created with BioRender. Contributed by Dr. Maria Chiara Manzini.)

Related Media

Associated Disorders

  • Agyria
  • Brain malformation
  • Buphthalmos
  • Cataract
  • Cerebellar malformation
  • Congenital muscular dystrophy
  • Corneal opacity
  • Dandy-Walker syndrome
  • Encephalocele
  • Glaucoma
  • Hydrocephalus
  • Lissencephaly
  • Microphthalmos
  • Optic nerve atrophy
  • Retinal detachment
  • Retinal dysplasia