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Model of GLUT1 structure

In this model of GLUT1 structure with 12 transmembrane domains, the main functional binding sites are (1) ATP binding sites, (2) the phosphorylation site, and (3) the sugar-binding site in position N317 of the transmembrane 8 (TM8) domain. (Source: Vulturar R, Chis A, Pintilie S, et al. One molecule for mental nourishment and more: glucose transporter type 1-biology and deficiency syndrome. Biomedicines 2022;10[6]:1249. Creative Commons Attribution License [CC BY], Figure edited by Dr. Douglas J Lanska.)