Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Lysosomal degradation of glycosphingolipids with responsible gene products and diseases connected to defects

Abbreviations: ASA, Arylsulfatase A; ASAH1, acid ceramidase; GALC, β-galactosylceramidase; GBA, β-glucocerebrosidase; GLA, α-galactosidase A; GLB1, β-galactosidase; HEXA, β-hexosaminidase A; HEXB, β-hexosaminidase B; NEU3/4, neuraminidase 3/4.

(Source: van Eijk M, Ferraz MJ, Boot RG, Aerts JM. Lyso-glycosphingolipids: presence and consequences. Essays Biochem 2020;64[3]:565-78. Creative Commons Attribution License 4.0 [CC BY],

Associated Disorders

  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy