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MRI pattern A2: MRI in late-infantile Krabbe disease

At 11.5 months, the central white matter shows abnormalities, whereas the cerebellar white matter appears normal (a). One month and 1.5 months later, the parieto-occipital white matter is increasingly involved, and the cerebellar white matter is still not affected (b, c). Six months later, frontal, central, and parieto-occipital white matter as well as cerebellum are affected (d). This patient had onset at 9 months. (Source: Krieg SI, Krägeloh-Mann I, Groeschel S, et al. Natural history of Krabbe disease: a nationwide study in Germany using clinical and MRI data. Orphanet J Rare Dis 2020;15[1]:243. Creative Commons Attribution 4.0 International [CC BY 4.0] license,

Associated Disorders

  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy