Brain metastases: considerations for surgical and radiosurgical treatment
Oct. 23, 2018
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From left to right: The lysosomal storage disorders, the gene defect, accumulating lysosomal GSL substrates, and the deacylated lyso-GSL species.
Abbreviations: ASA, Arylsulfatase A; GALC, β-galactosylceramidase; GalCer, galactosylceramide; GBA, acid β-glucosidase; GLA, α-galactosidase A; GLB1, β-galactosidase; GB3, globotriaosylceramide; GlcCer, glucosylceramide; GM1, ganglioside GM1; GM2, ganglioside GM2; HEX, β-hexosaminidase; lyso-GSL, lyso-glycosphingolipid; SO, sphingoid.
(Source: van Eijk M, Ferraz MJ, Boot RG, Aerts JM. Lyso-glycosphingolipids: presence and consequences. Essays Biochem 2020;64:565-78. Creative Commons Attribution License 4.0 [CC BY], https://creativecommons.org/licenses/by/4.0.)