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Chemical pathways affected in various sphingolipidoses

The sites of the chemical blocks are shown for GM1 gangliosidosis, Tay-Sachs disease, Krabbe disease, Sandhoff disease (or Sandhoff-Jatzkeqitz disease), Fabry disease, Gaucher disease, Krabbe disease (globoid cell leukodystrophy), metachromatic leukodystrophy, and Farber disease. (Illustration by Ebuxbaum, Sav_vas on April 15, 2009. Creative Commons Attribution-Share Alike 3.0 Unported License, https://creativecommons.org/licenses/by-sa/3.0/deed.en. Modified by Dr. Douglas J Lanska.)

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Associated Disorders

  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy