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CADASIL family pedigree

Typical pedigree demonstrating the transmission of CADASIL through 5 generations. The index patient is indicated with an arrow. In this family, the disease demonstrates a typical autosomal dominant pattern of inheritance with roughly half of all at-risk individuals displaying the phenotype. (Contributed by Dr. Daniel Bonthius.)

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Associated Disorders

  • Familial hemiplegic migraine
  • Subcortical stroke
  • Transient ischemic attack