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Small-vessel arteriopathy in the brain of a patient afflicted with CADASIL

(A) H&E stain reveals the replacement of smooth muscle cells in the media with an eosinophilic material. This pathologic change induces the apoptotic death of vascular cells, abnormal vascular tone, and narrowing of the vascular lumen (Gray et al 2007). (B) Periodic acid-Schiff stain highlights in magenta the deposition of material (arrow) within the arteriolar media. (Contributed by Dr. Steve Moore and Dr. Jill Hagenkord of the University of Iowa Department of Pathology.)

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Associated Disorders

  • Familial hemiplegic migraine
  • Subcortical stroke
  • Transient ischemic attack