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The 14.3.3 protein and its interaction with TDP-43

(From: Ke YD, van Hummel A, Au C, et al. Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice. Neuron 2024;112[(8]:1249-64.e8.)

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  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease