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Facets of astrocyte pathology in ALS/FTLD

Neuropathological inspection of postmortem material from ALS-FTLD patients revealed different aspects of astrocyte involvement, namely, (1) inflammation, (2) inclusion body formation, and (3) atrophy or degeneration. Whether these phenotypes correspond to different moments along a continuous timeline or whether they rather affect distinct subpopulations of astrocytes deserves further investigation. (From: Valori CF, Sulmona C, Brambilla L, Rossi D. Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia. Cells 2023;12[11]:1450. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

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