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Cryo-EM 3D maps and molecular models of TDP-43 amyloid fibrils

(From: Sharma K, Stockert F, Shenoy J, et al. Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils. Nat Commun 2024;15[1]:486. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease