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Interplay of IDR-rich proteins and mutants of folded proteins in LLPS and amyloid fibrillation, which is universally mediated by ATP and nucleic acids

(From: Song J. Molecular mechanisms of phase separation and amyloidosis of ALS/FTD-linked FUS and TDP-43. Aging Dis 2024;15[5]:2084-112. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease