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How dipeptide repeats inhibit ribosome function

(From: Loveland AB, Svidritskiy E, Susorov D, et al. Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commu 2022;13[1]:2776. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease