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Cryo-electron structures of TDP-43 amyloid filaments from individuals with Type A and Type B FTLD-TDP + ALS

(From: Arseni D, Chen R, Murzin AG, et al. TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP. Nature 2023;620[7975]:898-903. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease