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Immunohistochemistry demonstrating eastern equine encephalitis viral antigens in the thalamus

Histopathologic features from a 5-year-old girl with eastern equine encephalitis in 2005, as part of a study of eastern equine encephalitis in Massachusetts and New Hampshire from 1970 to 2010. The postmortem samples of central nervous system tissue were obtained 10 days after the onset of symptoms. Eastern equine encephalitis virus colocalizes with areas of tissue injury in the brain. Immunohistochemistry with eastern equine encephalitis immune ascites demonstrates eastern equine encephalitis viral antigens in the thalamus. Specificity for Eastern equine encephalitis virus immunoreactivity of this ascites fluid was confirmed by the lack of staining on control brain specimens. (Source: Silverman MA, Misasi J, Smole S, et al. Eastern equine encephalitis in children, Massachusetts and New Hampshire, USA, 1970-2010. Emerg Infect Dis 2013;19[2]:194-201. Public domain.)