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Neuropharmacology & Neurotherapeutics
Nov. 02, 2020
Asymptomatic hyperCKemia indicates a finding of persistent and abnormally high serum levels of creatine kinase (CK) in an asymptomatic person, whether or not the etiology has been found. An increased serum CK level is taken to mean that the integrity of the skeletal muscle membrane has been affected; an increased serum CK level is also a hallmark of muscle disease, either hereditary or acquired. Statin use is probably the most common cause of asymptomatic hyperCKemia.
May. 31, 2021
Childhood Degenerative & Metabolic Disorders
The term "acid sphingomyelinase-deficient Niemann-Pick disease" ("ASM-deficient NPD") or ASM deficiency (ASMD) is now preferred
Dec. 20, 2019
Autonomic neuropathies consist of acquired or inherited diseases resulting from a disturbance of the peripheral autonomic nervous system. Clinical features vary depending on relative involvement of distal sympathetic, cholinergic, or adrenergic systems.
Aug. 09, 2019
Paroxysmal dyskinesias are a relatively rare subset of hyperkinetic movement disorders that are defined by their episodic nature. They may be categorized into paroxysmal kinesigenic dyskinesia, paroxysmal nonkinesigenic dyskinesia, and paroxysmal exertion-induced dyskinesia. Paroxysmal dyskinesias may be sporadic, genetic, or caused by metabolic or structural etiologies. Another common cause of paroxysmal dyskinesias is psychogenic movement disorders.
Feb. 15, 2021
Sydenham chorea is the most common cause of acute chorea in children worldwide and is characterized by a random and continuous flow of contractions that spreads rapidly and becomes generalized. Evidence suggests that Sydenham chorea results from Streptococcus-induced antibodies that cross-react with central nervous system antigens. Neuropsychiatric symptoms, such as obsessions, compulsions, hyperactivity, and attention disorder, as well as depression, are often present in patients with Sydenham chorea.
Apr. 07, 2021
Varicella-zoster virus (VZV) central nervous system infection can have various presentations, including encephalitis, meningitis, cranial neuropathies, vasculopathy, and myelitis. The clinical manifestations of VZV infections can be divided into primary varicella zoster infection (chickenpox) and reactivated VZV infection (dermatomal shingles or disseminated herpes zoster). VZV is a neurotropic human herpesvirus, and the cause of neurologic complications has been postulated as either direct viral invasion through retrograde infection of neurons or immune-mediated mechanisms.
Jul. 12, 2020
Aug. 24, 2021