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The glutathione reductase enzyme utilizes FAD and NADPH as cofactors. Image by Zwickipedia (2014). (Courtesy of Wikimedia Commons. Creative Commons Attribution-Share Alike 3.0 Unported license.)
Headache & Pain
Jan. 19, 2021
Neuro-Ophthalmology & Neuro-Otology
Subjective tinnitus consists of a perceived sensation of sound that occurs in the absence of external acoustic stimulation, associated with hyperactivity of the auditory cortices involving the prefrontal cortex, orbitofrontal cortex, and the parieto-occipital region. It occurs most commonly as a result of cochlear dysfunction, with noise-induced hearing loss being the most common cause.
Oct. 21, 2020
Malignant hyperthermia is a hypermetabolic response to potent inhalational agents and/or succinylcholine that can lead to death. Most patients have no signs or symptoms prior to a malignant hyperthermia crisis. However, nonanesthesia-related cases of severe rhabdomyolysis linked to hereditary neuromuscular disorders or RYR1 or CACNA1S mutations are reported in the literature with increasing frequency.
Jun. 07, 2021
Neuropharmacology & Neurotherapeutics
Nov. 04, 2020
Dec. 26, 2020
Side-locked pain, provocation of typical headache by digital pressure on neck muscles and by head movement, and posterior-to-anterior radiation of pain are features that help distinguish cervicogenic headache from other primary headaches. There are many pain generators located in the cervical spine, and headaches caused by disorders of the neck can present with differing clinical features.
Oct. 23, 2016
Neurogenetics is a growing field that encompasses heritable disorders in all the subspecialties of neurology. Deciding on the genetic tests to order can be simplified by narrowing the differential diagnosis and defining the patient’s phenotype. Next-generation sequencing of the whole exome is useful for testing for multiple candidate genes simultaneously or for discovering new, rare disorders.
Oct. 07, 2019
Neuromyelitis optica, sensorimotor neuropathies, and other CNS involvement can be neurologic manifestations of Sjögren syndrome. Neurologic complications typically precede the diagnosis and appear in about 20% of patients. Sjogren is a chronic, multisystem autoimmune disorder.
Apr. 01, 2021