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Ribbon diagram (Richardson diagram) of glutathione synthetase. (Image by Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute. Courtesy of Wikimedia Commons. Public domain.)
Neuropharmacology & Neurotherapeutics
Oct. 05, 2021
Sleep bruxism is a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth or by bracing or thrusting of the mandible. A sequential change from autonomic and brain cortical activities precedes sleep bruxism, and growing evidence indicates that emotions, psychological stress and predisposition to anxiety can play a role in onset.
Oct. 27, 2020
Bowel dysfunction in neurologic diseases results from disturbance in the complex neural control of colonic function and defecation, and manifests primarily as constipation or fecal incontinence. The enteric nervous system is intrinsic to the wall of the gastrointestinal tract, and is influenced by the central nervous system via peripheral autonomic and somatic connections.
Oct. 11, 2020
Uremic neuropathy is a distal sensorimotor polyneuropathy caused by uremic toxins. Symptoms are insidious at onset. Paresthesias are usually the earliest symptoms; weakness and atrophy will follow the sensory symptoms. Chronic dialysis may prevent neuropathy in some patients, especially if begun early. Renal transplantation is generally the most successful method to prevent neuropathy.
Apr. 05, 2021
Aug. 05, 2020
Jul. 25, 2021
Childhood Degenerative & Metabolic Disorders
Hereditary galactosemia due to galactose-1-phosphate uridyltransferase (GALT) deficiency is 1 of the inborn errors of carbohydrate metabolism and can
Jan. 22, 2017
The congenital disorders of glycosylation syndromes constitute a group of severe syndromes with a broad phenotypic expression within and between subtypes. In most patients there are signs of nervous system involvement where typical manifestations include structural abnormalities, developmental delay, intellectual disability, stroke-like episodes, epileptic seizures, myopathies, myasthenia, and demyelinating neuropathy. A majority (60%) can be detected using a transferrin glycosylation test.
Jun. 01, 2013