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Axial noncontrast CT of the head shows subarachnoid hemorrhage (white arrows) in bilateral supratentorial sulci. (Contributed by Kristine Ann Blackham MD.)
Childhood Degenerative & Metabolic Disorders
Sep. 06, 2020
Stroke & Vascular Disorders
Mar. 04, 2021
Epilepsy & Seizures
Landau-Kleffner syndrome, or acquired epileptic aphasia, is an epileptic encephalopathy. Acquired aphasia is the more prominent feature because seizures are present in only 70% to 80% of patients. Verbal auditory agnosia is present in all patients, and in many cases the first diagnosis is hearing loss. Variable time may elapse between the loss of the ability to understand language and the expressive aphasia.
Jul. 26, 2021
Feb. 15, 2021
Neurologic complications from systemic anticancer therapies impact quality of life and remain an important source of dose-limiting toxicity. These complications may result from the direct toxic effects of the drug on the nervous system or indirectly from metabolic derangements, inflammatory responses, or cerebrovascular disorders induced by the drugs. The neurotoxicities of chemotherapy are widely known, but targeted agents and immunotherapies are also associated with neurologic complications.
Dec. 19, 2020
In patients with primary or isolated agenesis of the corpus callosum, IQ may be normal, but impaired processing between the hemispheres can be demonstrated by detailed psychometric testing and may manifest as deficits in learning and recall. Many genetic alterations have been etiologically linked to agenesis of the corpus callosum, both as isolated developmental events as well as in the context of syndromic clusters.
Aug. 24, 2021
Neuro-Ophthalmology & Neuro-Otology
By definition, multiple ocular motor palsies are present when eye muscle weakness, with or without anisocoria and ptosis, indicates dysfunction of more than one ocular motor nerve. The cardinal symptom is binocular diplopia, ie, double vision only when both eyes are open. Ophthalmoplegia caused by multiple ocular motor nerve palsies must be differentiated from that caused by single ocular motor nerve palsies, supranuclear gaze disorders, neuromuscular junction disorders, and myopathy.
Oct. 17, 2020
Hereditary amyloidosis is a disease caused by mutations in the transthyretin gene that lead to systemic deposition of amyloid protein. Although patients have multisystem involvement of amyloidosis, cardiomyopathy and peripheral neuropathy with autonomic neuropathy are typically the most prominent disease manifestations and the primary drivers of disability and mortality.
Feb. 18, 2021