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Temporal and spatial profiles of oligodendrocyte maturation

(A) Temporal profile of oligodendrocyte maturation showing that pre-oligodendrocytes, which are particularly vulnerable to hypoxia-ischemia, are the predominant cell type seen during the highest risk period for preterm white matter injury. (B) Spatial distribution of pre-oligodendrocytes varies over time. Abbreviations: OPC = oligodendrocyte precursor cells, pre-OLs = pre-oligodendrocytes, OL = oligodendrocyte. (Contributed by Dr. Vann Chau.)

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Associated Disorders

  • Global developmental delay
  • Hearing impairment
  • Intellectual disability
  • Neonatal hemorrhagic infarction
  • Respiratory distress syndrome
  • Seizures or epilepsy
  • Spastic diplegic cerebral palsy
  • Spastic quadriplegic cerebral palsy
  • Strabismus/visual impairment