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Punctate white matter lesion evolution

Punctate white matter lesion seen best on (A) brain MRI performed early in life compared to (B) MRI performed at term-equivalent age. (Contributed by Dr. Vann Chau.)

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Associated Disorders

  • Global developmental delay
  • Hearing impairment
  • Intellectual disability
  • Neonatal hemorrhagic infarction
  • Respiratory distress syndrome
  • Seizures or epilepsy
  • Spastic diplegic cerebral palsy
  • Spastic quadriplegic cerebral palsy
  • Strabismus/visual impairment