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Cystic white matter injury (MRI)

(A) Early in life and (B) term-equivalent-age MRIs show cystic changes consistent with cystic white matter injury or periventricular leukomalacia as well as an area of ischemic infarction in the posterior region. (C) Follow-up brain MRI performed at 8 years of age shows ventriculomegaly, distortion of the posterior horn of the lateral ventricles, and thinning of the white matter, including the corpus callosum, especially in the parieto-occipital lobes. (Contributed by Dr. Vann Chau.)

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Associated Disorders

  • Global developmental delay
  • Hearing impairment
  • Intellectual disability
  • Neonatal hemorrhagic infarction
  • Respiratory distress syndrome
  • Seizures or epilepsy
  • Spastic diplegic cerebral palsy
  • Spastic quadriplegic cerebral palsy
  • Strabismus/visual impairment